Adenomyosis and Fertility Causes, Effects on Pregnancy, and Treatment Options

Adenomyosis and Fertility: Causes, Effects on Pregnancy, and Treatment Options

Adenomyosis is a uterine condition that can cause painful periods, heavy bleeding, pelvic pain, and fertility concerns. It occurs when tissue similar to the uterine lining grows into the muscle of the uterus.

If you are trying to conceive, you may wonder whether adenomyosis affects your chances of pregnancy. Adenomyosis does not mean pregnancy is impossible, and many women conceive naturally or with fertility treatment.

Understanding how adenomyosis affects fertility and pregnancy can help you explore the right treatment and conception options with your doctor.

Table of Contents

What Is Adenomyosis?

Adenomyosis occurs when the tissue normally found lining the inside of the uterus, known as the endometrium, grows into the muscular layer of the uterine wall, called the myometrium.

This can cause the uterus to become enlarged or more bulky and may lead to inflammation and changes in the uterine muscle.

Adenomyosis is different from endometriosis, although the two conditions can occur together.

In endometriosis, tissue similar to the uterine lining grows outside the uterus, while adenomyosis involves the muscular wall of the uterus.

What Causes Adenomyosis?

The exact cause of adenomyosis is not fully known. Hormonal changes and changes where the uterine lining meets the uterine muscle may play a role.

It is more commonly diagnosed in women over 30 and may be associated with previous pregnancy or endometriosis.

Some factors linked with adenomyosis include:

  • Age: It is more often diagnosed after age 30.
  • Previous pregnancy: Adenomyosis may be more common in women who have been pregnant.
  • Endometriosis: The two conditions can occur together.
  • Hormonal activity: Estrogen and other reproductive hormones may influence the condition.

Having these factors does not mean you will develop adenomyosis. The condition can affect women of different ages and reproductive backgrounds.

Symptoms of Adenomyosis That May Affect Fertility

Adenomyosis can cause symptoms that affect your comfort, menstrual health, and sometimes your ability to conceive. Some women have mild symptoms, while others may have more noticeable problems.

Common symptoms include:

  • Heavy periods – Excessive menstrual bleeding can affect your overall well-being.
  • Painful periods – Strong cramps and pelvic pain are common signs of adenomyosis.
  • Pelvic pain – Ongoing discomfort may occur between periods.
  • Pain during sex – Some women experience pain during or after intercourse.
  • Bloating or pelvic pressure – An enlarged uterus may cause a feeling of fullness or pressure.
  • Irregular bleeding – Bleeding between periods or changes in your normal cycle may occur.

Not everyone with adenomyosis has fertility problems.

However, if you have persistent symptoms while trying to conceive, speaking with a fertility specialist can help identify the cause and discuss suitable treatment options.

How Does Adenomyosis Affect Fertility?

Adenomyosis may make it harder to become pregnant by changing the uterus and affecting embryo implantation.

Inflammation and changes in the uterine muscle may also affect how the uterus functions.

It may affect fertility by:

  • Making implantation harder
  • Causing inflammation in the uterus
  • Changing normal uterine contractions
  • Increasing the risk of some pregnancy problems

However, adenomyosis does not mean you cannot get pregnant. Many women conceive naturally or with appropriate fertility treatment.

Adenomyosis and Natural Pregnancy

Yes, it is possible to get pregnant naturally with adenomyosis.

Having this condition does not automatically mean you will need fertility treatment or that you cannot have a healthy pregnancy.

Some women with adenomyosis conceive without medical help, especially when there are no other fertility problems. However, the condition may affect fertility in some cases, so it is important to consider your overall reproductive health.

If you have been trying to conceive without success, a fertility test can help identify possible causes.

Your doctor may check ovulation, ovarian reserve, sperm health, fallopian tubes, and the uterus before recommending the next step.

Adenomyosis and Pregnancy: Possible Risks

Adenomyosis does not mean you cannot have a healthy pregnancy. However, it may increase the chance of some complications.

These may include:

  • Miscarriage – the pregnancy may be more likely to end early.
  • Early birth – there may be a higher chance of giving birth before the due date.
  • Bleeding – some women may experience pregnancy-related bleeding.
  • Placenta problems – the placenta may not attach or function normally.
  • Lower birth weight – some babies may be born smaller than expected.

The risk is different for every woman. Regular pregnancy care can help your doctor monitor your health and your baby’s development.

How Is Adenomyosis Diagnosed?

Adenomyosis is usually diagnosed by looking at your symptoms and examining the uterus with imaging tests. The main tests include:

  • Transvaginal ultrasound – gives a detailed view of the uterus and can show changes linked to adenomyosis.
  • MRI scan – provides a clearer image of the uterine muscle and may be used when more detail is needed.
  • Pelvic examination – your doctor may check for an enlarged or tender uterus.

Your doctor may also check for other conditions, such as fibroids or endometriosis, which can cause similar symptoms.

Adenomyosis Treatment Options When Trying to Conceive

If you are trying to get pregnant, treatment for adenomyosis should help manage symptoms without unnecessarily affecting your fertility.

Your doctor may consider options based on the severity of your condition and your pregnancy plans.

Common options include:

  • Pain medicines – can help control period pain and discomfort.
  • Hormonal treatment – may reduce symptoms but usually prevents pregnancy while you are using it.
  • Fertility treatment – options such as IUI or IVF may be considered if conception is difficult.
  • Uterus-sparing surgery – may be considered in selected cases when adenomyosis is severe.

The best treatment depends on your individual situation, so a fertility specialised clinic can help you choose an approach that supports both symptom control and your pregnancy goals.

Fertility Treatment for Women With Adenomyosis

If natural conception does not occur, fertility treatment may be considered based on the complete fertility assessment.

Depending on your circumstances, options may include:

The best option depends on factors such as age, ovarian reserve, sperm quality, fallopian tube health, duration of infertility, and the severity of adenomyosis.

Adenomyosis Treatment Before IVF

For some women undergoing IVF, a fertility specialist may consider treating or suppressing adenomyosis before embryo transfer.

One approach involves medicines that temporarily suppress ovarian hormone activity, such as GnRH agonist treatment.

However, there is no single pre-IVF treatment that is appropriate for everyone.

Current evidence remains limited, and ASRM notes that more high-quality research is needed to determine which patients are most likely to benefit from specific treatments before embryo transfer.

Your fertility specialist may therefore consider the severity of adenomyosis, previous IVF outcomes, age, ovarian reserve, and other reproductive factors before creating a treatment plan.

Can Adenomyosis Be Treated Without Affecting Fertility?

Yes, some treatments can help manage adenomyosis while preserving your ability to become pregnant.

The right option depends on your symptoms, the severity of adenomyosis, and whether you are trying to conceive now.

Common fertility-friendly approaches may include:

  • Pain relief – Medicines can help manage pelvic pain and painful periods.
  • Symptom management – Some treatments can control heavy bleeding and other symptoms without surgery.
  • Fertility treatmentIUI or IVF may be considered when adenomyosis makes natural conception difficult.
  • Uterus-sparing surgery – In selected cases, surgery may be considered to remove or reduce adenomyosis while keeping the uterus.

Hormonal treatments can control adenomyosis symptoms but usually prevent pregnancy while you are using them.

Your doctor can help choose a treatment that balances symptom control with your plans for pregnancy.

Improving Your Chances of Pregnancy With Adenomyosis

If you have adenomyosis and want to become pregnant, consider discussing the following with a fertility specialist:

  1. Understand the extent of adenomyosis. Imaging can help determine how the uterus is affected.
  2. Check for other fertility factors. Adenomyosis may not be the only reason conception is difficult.
  3. Consider your age and ovarian reserve. These factors are important when deciding how long to try naturally.
  4. Treat significant symptoms. Heavy bleeding and pelvic pain should not simply be ignored.
  5. Plan fertility treatment early when appropriate. IVF or another fertility treatment may be considered when natural conception is unlikely or has not occurred.
  6. Discuss treatment before embryo transfer. If IVF is planned, ask whether pretreatment for adenomyosis is appropriate in your individual case.
  7. Work with a fertility specialist familiar with adenomyosis. Treatment should be personalized rather than based on the diagnosis alone.

Final Verdict

Adenomyosis can make pregnancy planning more challenging, but it does not mean you cannot become pregnant. Many women conceive naturally, while others may benefit from fertility treatment or medical care.

The right approach depends on your symptoms, age, fertility goals, and the severity of adenomyosis. A proper evaluation can help identify the best treatment and conception options.

With personalized care and the right support, adenomyosis does not have to prevent you from pursuing your goal of becoming a parent.